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10.1016/j.brainresbull.2021.05.001 88 NewtonR.KuitertL

The most pronounced differences were observed across gastrointestinal and metabolic events, including nausea (9,651 vs 38,030), vomiting (4,383 vs 17,062), pancreatitis (1,389 vs 6,655), and hypoglycaemia (773 vs 1,778), all substantially lower with combination therapy (Table 1)

Written informed consent was obtained from the subjects parents, and verbal assent was obtained from all the study subjects before drawing blood